Unfortunately, it looks like the latest release of OSX 11 (Big Sur) has made breaking changes in relation to how the version of Mozilla Komodo is using works with the OSX SDK. We’re currently investigating the scope of this problem. At this time we advise that Komodo users remain on OSX 10.x.
You’ll likely hit the issue when Komodo Edit tries to open a dialog, eg. closing Komodo when a file has unsaved changes.
In my testing, Komodo Edit does not work. This is breakage in the older version of Mozilla we use which is common across all releases of Komodo all the way back to Komodo 8, Edit or IDE.